Premier League Gameweek 5 Predictions & Betting Odds 2025/26: Top Fixtures Preview
Introduction
The excitement of the Premier League continues to mount as Gameweek 5 approaches, promising an action-packed weekend filled with crucial battles and high stakes. From the intense Merseyside Derby between Liverpool and Everton to a fiery clash at the Emirates with Arsenal hosting Manchester City, football fans and bettors alike are bracing for a rollercoaster of results.
This article breaks down the top fixtures of Gameweek 5 with expert predictions, player insights, and the latest betting odds. Whether you’re aiming to optimise your Fantasy Premier League picks or looking for reliable betting tips, this guide has it all.
Gameweek 5 Fixture Predictions
Liverpool vs Everton

Liverpool have been scraping together late winners despite some inconsistency, while Everton have impressed under David Moyes’s leadership. However, Liverpool’s elite squad depth should see them edge this derby with a 2-1 victory.
Prediction: Liverpool 2-1 Everton
Burnley vs Nottingham Forest

Nottingham Forest had a harsh 3-0 defeat to Arsenal but are expected to rebound strongly at struggling Burnley. Forest should secure a solid 3-1 win as they seek momentum.
Prediction: Burnley 1-3 Nottingham Forest
Brighton vs Tottenham Hotspur
Both teams offer exciting, attacking play, but Spurs’ recently solid defence under Thomas Frank gives them the upper hand.
Prediction: Brighton 1-3 Tottenham Hotspur
West Ham vs Crystal Palace
After a disappointing loss to Tottenham, West Ham face a tough test against Crystal Palace, who are the favourites to claim a 2-0 win.
Prediction: West Ham 0-2 Crystal Palace
Wolves vs Leeds United
Wolves remain pointless so far, while Leeds have been better than expected. A draw seems the most likely outcome.
Prediction: Wolves 1-1 Leeds United
Manchester United vs Chelsea

Both sides underperformed last week. Chelsea are favoured to bounce back with a convincing 3-1 win over Manchester United at Old Trafford.
Prediction: Manchester United 1-3 Chelsea
Fulham vs Brentford
Two mid-table teams likely to share the spoils in what could be an entertaining but evenly matched 2-2 draw.
Prediction: Fulham 2-2 Brentford
Sunderland vs Aston Villa
Sunderland continue their surprising form, and Aston Villa’s tough start points to a home win for Sunderland.
Prediction: Sunderland 2-1 Aston Villa
Bournemouth vs Newcastle
Both teams have shown quality under new management, with Bournemouth slightly favoured in a close 3-2 game.
Prediction: Bournemouth 3-2 Newcastle United
Arsenal vs Manchester City

A highlight fixture featuring master vs apprentice, Mikel Arteta vs Pep Guardiola. With City’s fatigue from a tough Champions League schedule and Arsenal’s strong home form, the Gunners are heavy favourites.
Prediction: Arsenal 3-1 Manchester City
Premier League Gameweek 5 Betting Odds & Picks
- Liverpool vs Everton: Expect a penalty to be awarded in this fiery derby, with Liverpool favoured but Everton pushing hard.
- Manchester United vs Chelsea: Patrick Dorgu (Man Utd) is predicted to have 2 or more shots, as United looks to exploit Chelsea’s weakened defence.
- Arsenal vs Man City: Both teams are expected to score, with an exciting end-to-end match on the cards.
- Burnley vs Nottingham Forest: Burnley to score first, capitalising on Forest’s defensive vulnerabilities.
- Everton: Strong contenders to finish in the Premier League top six, with odds improving after a solid start.
Key Players to Watch
- Mohamed Salah (Liverpool): Always a top pick for Fantasy and bouts of crucial goals.
- Erling Haaland (Man City): In pursuit of another Golden Boot.
- Jack Grealish and Kiernan Dewsbury-Hall (Everton): Driving Everton’s surprising early-season success.
- Patrick Dorgu (Manchester United): Central to United’s attacking plays.
Conclusion
Gameweek 5 of the Premier League 2025/26 season offers a treasure trove of exciting fixtures packed with drama, goals, and unexpected results. Whether backing bets or setting fantasy lineups, the insights provided here aim to help make the most of this pivotal round.
Make sure to watch every moment of the Merseyside Derby, Arsenal’s title showdown with Manchester City, and all the other action this weekend.